چكيده لاتين :
Background: Non-steroidal anti-inflammatory drug (NSAID)
use and H pylori infection are two major causes of peptic ulcers .
This study investigates the effect of H pylori infection and
NSAIDs on gastroduodenal damages and bleeding (GIB).
Methods: 104 patients with acute gastrointestinal bleeding
(GIB) and 102 patients with dyspepsia without bleeding were
studied. Duodenal (DU) and gastric ulcers (GU) were identified
by endoscopy and H pylori infection by histologic examination
of biopsy samples. Association ofNSAID and H pylori
with DU, GU and/or GIB was determined by calculation of
odds ratio.
Results: The percentages ofNSAID-users in patients with and
without GIB were 50% and 34% respectively. DU and GU
were more frequent in patients with GIB than those without
bleeding (P<0.001) . In NSAID-users, the percentages of DU
as well as GIB were s ignificantly higher as compared with
non-users (P <0.02). Concerning H pylori-infected as compared
to non-infected patients, the prevalence of DU was significantly
higher (P<0.000). The percentage of GU was significantly
lower (P<0.02).DU was significantly higher in
NSAID-users who were infected with H pylori than those of
non-infected (P<0.001), but such a relationship was reversed
with respect to GU (P<0.0015). However, the rate of GIB in
this group was not decreased significantly.
Conclusion: H pylori infection increased the risk of DU in
NSAID users, whereas, it decreased the risks of GU and GIB
in NSAID and GU in non users.
