18941

2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium Tetrafluoroborate as an Efficient Coupling Reagent for the Amidation and Phenylhydrazation of Carboxylic Acids at Room Temperature

Balalaie S. نويسنده , Mahdidoust M. نويسنده , Eshaghi-Najafabadi R. نويسنده

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369

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The synthesis of amides and phenylhydrazides from the reaction of corresponding carboxylic acids with primary aliphatic, aromatic amines or phenylhydrazine in the presence of triethylamine or diisopropylethyl amine as a base using 2-(1Hbenzotriazole- 1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) proceeds smoothly under mild conditions to afford the corresponding amides or phenylhydrazides in good to high yields in ethyl acetate at room temperature.

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