پديد آورندگان :
Barekatain M نويسنده , Fatemi A نويسنده , Bashardoost N نويسنده , Darougheh A نويسنده , Salehi M نويسنده , Asadollahi GH نويسنده
چكيده لاتين :
We evaluated the efficacy of valproate plus risperidone versus valproate plus lithium combination in the
treatment of acute mania.
Methods: In 2-week, randomized, double-blind, parallel group study , 46 acute manic patients according to DSM-IV
criteria were randomly assigned to receive combination of valproate 20 mg/ kg/day plus risperidone 2-4 mg/day (n""23)
or lithium600- I200 rug/day (n=23). The assessment of efficacy measures were according to Young Mania Rating Scale
(YMRS) and Clinical Global Impressions-Severity (CGI-S) and Improvement (CGI-I) scale. Other effectiveness measures
included YMRS response (YMRS reduction;::50 %) and YMRS remission (YMRS total scores ~12).
Results: In each group, 16 of23 patients (70 %) completed the study. YMRS response, CGI-Improvement, and reduction
in the total scores ofYMRS and CGI-S observed in both groups, significantly greater for valproate-risperidone than
valproate-lithiurn combination group (P=0.006, P=O.015, P=0.004, and P""0.007, respectively).YMRS remission were
shown in both groups without statistical significance (p=O.073). The total scores of YMRS at 4th
, 8th
, and 14th days of
trial were lower in valproate-risperidone than valproate-lithium combination group (P=0.017, P=0.005, and P""O.004,
respectively). The rate of adverse events and mean weight gain in both groups were not statistically different.
Conclusion: In acute manic patients, both combinations of valproate with lithium or with risperidone had efficacy in
acutely manic patients, but valproate-risperidone combination was more effective. Both treatments were safe and well
tolerated. Considering the small sample size and limited period of observation, further studies need to be conducted to
find out the best combination in the treatment of acute mania.