چكيده لاتين :
Background: A wide range of preventive medications for migraine
attacks, with varying efficacy is currently in use, Studies
comparing the efficacies of these drugs would be of value in the
proper treatment of the disease. The present study compared the
frequency, duration and intensity of migraine attacks during and
following treatment with cyproheptadine (4 mg, twice daily) or
Blellergal (belladonna 0, I mg, ergotamine 0,3 mg and phenobarbital
20 mg).
Methods: 118 patients 15 to 45 year-old with migraine headaches
were randomly allocated to groups I (n=36), II (n=40)
and III (n=42) and treated during three consecutive phases of
45 days. In phase one all groups received two oral placebo
tablets daily. In phase two, group I continued with placebo,
groups II and III received cyproheptadine (4 mg, twice daily)
and Bellergal (three tablets daily), and finally, in phase three
all groups were treated with placebo, respectively,
Results: Cyproheptadine and Bellergal treatments significantly
reduced the frequency, duration and intensity of migraine
attacks. These parameters remained low during phase
three (placebo) in cyproheptadine treated patients as compared
to those who only received placebo, But there was a rebound
effect following discontinuation of Bellergal.
Conclusion: Cyproheptadine and Bellergal seem to preventive
migraine attacks. Cyproheptadine is a preferred choice
because its effects were partially preserved following withdrawal.
