چكيده لاتين :
The effect of aqueous extract of Nepata glomerulosa Boiss. aerial parts on
morphine withdrawal syndrome was investigated in mice. Dependence was induced
by subcutaneous injections of morphine for 3 consecutive days. On day 4, morphine
was injected 2 h prior to intraperitoneal injection of naloxone. The number of
jumps during a 20 min. period after naloxone injection was considered as a measure
of the withdrawal syndrome. Open field and rotarod tests were also performed. The
results indicated that the aqueous extract (0.1 to 2.8 g/kg, s.c.) and diazepam (5 mg/kg)
reduced the number of jumps (58±2.3 to 10±0.82, p<0.001 vs normal saline,
87±3.4). The extracts also reduced motion balance and locomotion activity. It is
concluded that the aqueous extract of N. glomerulosa aerial parts could diminish
morphine withdrawal syndrome.
