چكيده لاتين :
The overall incidence of glucose-6-phosphate dehydrogenase
(G6PD) deficiency in Iranian population is estimated around
10%-14.9%. G6PD deficiency is an X-linked disorder and 80%
of donors are usually male. At present, donorsי blood is not routinely
screened for G6PD deficiency in Iran blood bank where
for detecting such enzyme deficiency, reliance is placed on predonation
data. Thus, the G6PD deficient blood may be transfused
to G6PD deficient premature neonates, resulting in prolonged
or severe hyperbilirubinemia. Fluorescent spot method
was used to determine G6PD deficiency in 450 blood samples
collected from male donors stored less than 7 days. This was
followed by the pre-donation questionnaires for the history of
previous diseases or jaundice. Of which 27 (6%) samples were
G6PD deficient. None of the donors tested for G6PD deficiency
recalled, and stated in their pre-donation questionnaires, any
history of previous diseases or jaundice.
Six percent G6PD deficiencies among the male donors in
Shiraz blood bank was a noteworthy prevalence, which was
independent of the pre-donation questionnaires. Therefore,
regardless of the questionersי data, it was recommended to
screen the blood bags for this enzyme prior to use for simple
or exchange transfusion in premature infants.
