چكيده لاتين :
The search for indigenous natural antidiabetic agents is still ongoing. Securigera
securidaca seeds are reputed in folk medicine for their value as an antidiabetic remedy,
so the present study was carried out to investigate the hypoglycemic efficacy in both
normal and streptozotocine (STZ)-induced diabetic rats. Hydroalcoholic extract of
the seeds were administered orally with doses of 200, 400, and 800 mg/kg and
intraperitoneally with a dose of 400 mg/kg to separated groups of male Wistar rats.
The control and reference groups received oral vehicle (1 ml/kg) and glibenclamide
(10 mg/kg, p.o.), respectively. Blood samples were collected at 0, 1, 2, 3, 4, and 8
h after treatment and blood glucose levels were determined using glucose oxidase
method. Results indicated that hydroalcoholic extract of S. securidaca was not
effective to lower blood glucose level both in normal and diabetic rats. Glibenclamide
on the other hand, reduced blood level of glucose in diabetic rats and caused
hypoglycemia in normal animals and the effect was time-dependent. It is concluded
that seeds of S. securidaca were not effective to reduce blood glucose level in this
animal model of diabetes.
