پديد آورندگان :
Karimzadeh H نويسنده , Nazari J نويسنده , Mottaghi P نويسنده , Kabiri P نويسنده
چكيده لاتين :
Gout is a Common recurrent clinical syndrome characterized by increased serum uric acid and recurrent
attacks of acute arthritis . Colchicine is used for Prophylaxis against recurrence of arthritis, but the duration of its
administration has mentioned variable. In this study, optimal duration of prophylactic colchicine for prevention of gouty
arthritis was assessed.
Methods: In a clinical trial 190 patients with gouty arthriti s divided randomly to group 1,2and 3 and received colchicine
for 3 to 6, 7 to 9 and 10 to 12 months then colchicine discontinued and the patients followed one year for reeurrence of
arthritis . Result assessed by surviv al analysis with Kaplan -Meier method.
Results: The probability of recurrence of arthritis (in order of duration of colchicine prophylaxis) was 54%, 27.5% and
23%, respectively. The difference between group one and others was statistically significant, but between group 2 and 3 was
not statistically significant.
Conclusion: The most suitable duration of colehieine prophylaxis that accompanied with lower recurrence rate was 7-9
months, which seems more cost -effective than 10-12 months regimen .
