عنوان به زبان ديگر :
Role of HLA-B7, B8, B27, and B51 in Protection aga.inst Hepatitis B Virus Infection
چكيده لاتين :
Background: It has been argued that unprecedented degree of
human leukocyte antigen (HLA) loci polymorphism within a
population is required to avoid the devastating effects of infectious
diseases. The present study was conducted to determine
the associations between some of HLA class I genes and the
outcome of hepatitis B virus (HBY) infection.
Methods: Using sequential sampling method, 64 individuals
were selected and categorized into two groups according to
their clinical and serological profiles . The patients in the case
group were 27 patients with chronic HBY infection and the
controls were 37 individuals considered as HBY natural convalescent
who recovered from HBY infection . Antibodies
against HBsAg (anti-HBs) and hepatitis B core antigen (antiHBc)
were assessed to exclude primary HBY infection. Individuals
with viral clearance were positive for anti-HBs and
anti-HBc without the presence of HBsAg at two time points.
HLA typing was performed by serological method. Collected
data were analyzed by SPSS software version 13.
Results: The most frequent HLA antigens among the studied
subjects were B51 (40 . 1%), B27 (14 .1%), B8 (12.5%), and
B7 (10.9%). A significant correlation was found between
HBY persistence and HLA-B27 (P <0.05). The association
between other HLAs (HLA 7, 8, 57) with HBY clearance was
not significant. The two studied groups were statistically different
in sex but not in age.
Conclusion: Findings of the present study demonstrated an association
between HLA class I and outcome of HEY infection
where HLA B27 was linked to an increase in HEY persistence.
These findings support the hypothesis that HLA class I-restricted
cytotoxic T cells play an important role in HBY chronicity.
