پديد آورندگان :
BASIRATNIA M. نويسنده , FALLAHZADEH M. H. نويسنده , DERAKHSHAN A. نويسنده , HOSSEINI AL HASHEMI G. نويسنده
چكيده لاتين :
Background: Given the high relapse rate of disease in children
with steroid dependent nephrotic syndrome and the osteoporotic
effect of long periods of steroid therapy, this survey was performed
to find the bone mineral status of these patients.
Methods: Bone mineral density and content (BMO and BMC)
were measured using Dual energy X-ray absorptiometry in 37
nephrotic children, six girls and 31 boys aged from four to 21yrs,
as patient group and 37 age and sex-matched healthy individuals
as control group. Historical data were collected by
chart review.
Results: As compared to the control group, the patients were
shorter in stature. The percentage of BMC of lumbar and
BMO of femoral bones of the patients was significantly
lower than control group. According to the Warner method,
12% of the patients were osteoporotic and the BMO of their
femoral and lumbar bones was inversely correlated with cumulative
steroid dose.
Conclusion: Bone loss can occur in some steroid-dependent
nephrotic patients, especially those with low age of onset and
those with longer duration of the disease and higher cumulative
dose of steroid. Therefore, measurements of BMO and BMC
could be recommended, at least, for the selected patients