چكيده لاتين :
The binding of drugs by plasma proteins is an important phenomenon, because
it influences the size of the free fraction of the drugs in plasma. In this study the
influence of dipyridamole (DP) on the protein binding of propranolol (PL) and PL
on the protein binding of DP were studied alone and in the presence of nicotine (NC).
The equilibrium dialysis was employed for protein binding studies. Results showed
that DP (10 ىg/ml) increased the protein binding of PL (1-40 ىg/ml) by 4.1%, and
PL(30 ىg/ml) decreased the protein binding of DP (1-30 ىg/ml) by 3.7%. NC (2 ىg/ml)
did not have any influence on the protein binding of PL and DP. Therefore, coadministration
of PL and DP may cause an alteration in their pharmacological effects,
but cigarette smoking possibly does not change protein binding of PL and DP.
