چكيده لاتين :
Poly-(alkylcyanoacrylate) ester particles have been used for the preparation of different
formulations ranging from ophthalmic delivery systems to cancer chemotherapy carriers in
clinic. The aim of this study was to prepare and characterize poly-(methyl ethyl cyanoacrylate)
(PMECA) particles containing 5-aminosaJicylic acid (5-ASA). PMECA particles were prepared
using the inverse emulsification polymerization technique. The effects of various formulation
parameters such as dispersed phase volume, polymer to drug weight ratio, and surfactant
concentration on loading efficiency and size of the prepared particles were investigated.
The amount of drug was determined by UY spectrophotometery at 331 nm. Morphological
characteristics of particles and particle size analysis were studied by Scanning Electron
Microscopy (SEM) and Laser Light Scattering techniques, respectively. The results showed
that there was no linear relationship between the dispersed phase volume (DPY) and loading
efficiency of 5-ASA in the range of 20-50%. Increasing polymer/drug weight ratio in the
range of I- 15, enhanced the loading efficiency from 11.4 to 78.2% in a linear mode (r=0.987).
Increasing the surfactant concentration in the range of 1-3% did not increase the loading
efficiency of the prepared particles, and increasing the concentration to 5% even decreased the
loading efficiency of particles. Laser light scattering and SEM evaluations showed that in all
prepared formulations, particles were in a mixture of micro and nanospheres and micro and
nanocapsules and 50 percent of particles had mean sizes in the range of 6.4-10.1 micrometer.
Although our results showed significant differences in the mean particle size between some of
the prepared formulations, this variation was not practically important. It was concluded that
by using proper conditions, it is possible to use PMECA as a polymeric matrix for loading of
5-ASA and the other hydrophilic drugs
