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Anticonvulsant Activities of 7-phenyl-SH-thiazolo [S,4-e] [1,2,3,4] tetrazolo[S,I-c]pyrrolo[I,2-a] [1 ,4]diazepine and 7-phenyl-SH-thiazolo[S,4-e\[1,3,4]triazolo[S,I-c] pyrrolo[I,2-a] [1,4]diazepines

Maryam Maryam نويسنده , Binesh Marvasti Marya نويسنده , Sharifzadeh Mohammad نويسنده , SHAFIEE ABBAS نويسنده

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Anticonvulsant activity of7-phenyl-5H-thiazolo[5,4-e][ I ,2,3,4 ]tetrazolo[5, l-c]pyrrolo[ 1,2a][ 1,4]diazepine (5) and 7-phenyl-5H-thiazolo[5,4-e][ I ,3,4]triazolo[5, l-c ]pyrrolo[ 1,2a][ 1,4]diazepines (6a-d) was measured against pentylenetetrazole (PTZ)-induced seizures in mice. Intraperitoneal injections of different doses (12.5, 25 and 50 mg/kg, i.p.) of test compounds decreased PTZ-induced seizure significantly in a dose-dependent manner.The test compounds were administered 30 min befor PTZ (80 mg/kg, i.p.) injection. The maximum response was obtained with 50 mg/kg ofcompound 6d that showed more anticonvul sant activity compared to diazepam (0.5 mg/kg). The frequency of mortality was also decreased by all listed compounds. Pretreatment of animals with flumazenile (as a benzodiazepine, BDZ receptor antagonist) decreased, but not completely inhibited the anticonvulsant activity of compound 6d (50 mg/kg). These results indicate that besides BZD receptors, other neurotransmitter systems may be involved in anticonvulsant activity of the tested compounds.

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