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The CYP1A1 and GSTM1 Genetic Polymorphisms and Susceptibility to Endometriosis in Women from South India

Rozati Roya نويسنده , Baludu Giragalla Simha نويسنده , Bakshi Hamid نويسنده , Doddamanen Srikanth نويسنده , Khaja Nasaruddin نويسنده , Sham Sharma Radhey نويسنده

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Background: Endometriosis is one of the most commonly encountered benign problems in gynaecology. It is freq uently associated with chronic pelvic pain, dysmenorrhoea, menorrhagia and dyspareun ia, which lead to infertility. We determined the poss ible association between CYP IAI MspI and GSTM I null polymorphism in the pathogenesis fendometriosis. Materials and Methods: Ninety seven cases of endometriosis diagnosed by laparoscopy and one hundred two women without endometriosis were laparoscopically confirmed. Genomic DNA of heparinised blood were collected and null gene polymorphisms in GSTM I and CYP IAI genes coding for detoxification enzymes were identified by the PCR-based restriction fragment length polymorphism (RFLP) method. Results: The GSTM I null mutation showed significant association (p