مرکز منطقه ای اطلاع رساني علوم و فناوري -

چكيده لاتين :

The endometrium is a highly dynamic tissue empowered with the capacity to undergo cycl ic dramatic changes in respon se to ovari an steroid hormones, ultimately aiming to create a window of receptivity for blastocyst implantation. Inten sive research has been performed to understand and establish morphological and molecular correl ates of embryo implantation. However, it still remains a biologi cal mystery particularly in the human, where ethical and moral constraints prohibit in vivo testing and the establ ishment of an ideal in vitro modeling. Rodent models of embryo implantation are largely irrelevant because the proce ss varies significantly from that in humans. Even among primates, subtle differences exist among species . For maternal preparation of implantation, the endometrial epithelium which is surprisingly hostile towards the embryo implantation, acqui res functional status recepti ve to blastocyst acceptance during a limited period of cycle days, term ed as the יwindow of implantation (WOI) . This review provide s currently ava ilable information concerned primarily with the various ultrastructural modifications of endometrium coordinated within the WOI that may signify endometrial receptivity. In the followin g sec tions, the dominant feature s ofendometrial differentiation during WOI, including transformations ofluminal epithelium, endom etr ial gland s, and stromal decidualization will be discussed from the morph ological points of view. Lipid peroxidati on is known to cause variou s impairments to sperm cells and may playa major role in the etiol ogy of male infertility.Asthen ospermia is the main factor of male infert ility and has significantly higher level of peroxid ation than in normozoospermic males.