مرکز منطقه ای اطلاع رساني علوم و فناوري -

چكيده لاتين :

Background: Lipid peroxidation is known to cause various impairments to sperm cells and may playa major role in the etiology of male infertility. Asthenospermia is the main factor of male infertility and has significantly higher level of peroxidation than in normozoospermic males. Materials and Methods: Using thiobarbituric acid (TBA) assay procedure, we have determined the level of lipid peroxidation as indicated by malondialdehyde(MDA)in the spermatozoa obtained from asthenospermic male semen. Results: An inverse correlation of MDAconcentration with sperm motility is observed. Treatment of cells with L-arginine and vitaminEsignificantly decreases theMDAconcentration and improves the sperm motility as compared to that in case of control samples.Acombination of L-arginine and vitamin E shows synergistic effect on sperm motilityand prevention of lipid peroxidation. Conclusion: L-arginine and vitamin E protect the cells against the loss of sperm motility by lipid peroxidation. Therefore, supplementation of both L-arginine and vitamin E may improve sperm motility and increase the possibility of fertilization in asthenospermic subjects.