چكيده لاتين :
Mefloquine (MFQ), as a racemic mixture is used for the prophylaxis and
treatment of malaria. Stereoselective pharmacodynamic and pharmacokinetic
differences have been observed for MFQ. In the present study, the human blood was
spiked with racemic MFQ. The concentration of MFQ enantiomers in various
blood fractions including packed erythrocyte layer, platelet rich plasma and platelet
poor plasma was determined. The results showed that the ratio of (+)-MFQ was about
1.5 time higher than (-)-MFQ in packed erythrocyte layer. Results obtained from
the separated erythrocytes spiked with racemic MFQ showed no significant
difference between the enantiomer concentrations. It can be concluded that the stereoselective
accumulation of MFQ enantiomers in erythrocytes might be in relation
to protein binding or the presence of other blood cells.
