چكيده لاتين :
Calcium acetate is used as an oral phosphate binder to control hyperphosphatemia
in patients with chronic renal failure. Compared to calcium carbonate,
control of hyperphosphatemia can be achieved at lower calcium administration with
calcium acetate which likely reduces the risk of hypercalcemia. In this study,
various formulations of calcium acetate tablets were prepared and their disintegration
times, dissolution rates and phosphate binding capacities were determined. Dissolution
test was carried out using the paddle method according to the United States
Pharmacopoeia (USP XXIII). The binding efficiency of the tablets was compared
by measuring the amount of insoluble phosphate after mixing with a sodium
phosphate solution at pH 6. Calcium acetate tablets had a mean content of 809.6 mg
of calcium acetate and a mean weight of 1087 mg. The average breaking load and
disintegration times were 66.4±5.5 N and 24.5±2.1 min, respectively. Drug release
after 30 and 60 min were 80.45% and 101.42%, respectively. The amount of nondissolved
phosphorus following 60 min incubation of calcium acetate and/or
calcium carbonate tablets were 372.8 mg (61.2%) and 463.2 mg (76.0%), respectively.
Weight variation, friability, disintegration time, and dissolution rate of calcium
acetate
