مرکز منطقه ای اطلاع رساني علوم و فناوري -

چكيده لاتين :

Saffro n (Zaaferan), botanical name Crams sal/pus, is the most expensive spice in the world. It is derived from the dri ed stigma and pistil of the purple saffro n crocus flowers. Iran is the largest saffron pro du cer accounting for more than 80% of th e worldיs production. Saffron contains an aero allergen that causes reactiv e respi ratory allergic reaction s in atop ic subjects. IgG antibody to allergen s in the serum of allergic patients is not routinely mea sur ed . In this study in order to find out more abo ut mechanism of allergy against saffron pollen, specific antibo dies (igE and IgG, total and subclasses) in atopic subj ect s were assayed. We used an ELISA assay for measuring specific IgE and IgG against saffron pollen extract in the sera of 38 atopic subjects (test group) and 20 non allergic subjects (contro l gro up). The optical densities were compared between allergic subj ect s and non -allergic individuals. The prick test with saffro n pollen extract was used to evaluate th e cutaneou s and specific antibo dy resp on ses in th e allergic subjects. The correlation was determined by statistical analysis. Specific saffron pollen IgE and IgG subclasses were found significantly high er in the allergic subjects than the control group. The immediate skin reaction was found positive in 70יYo of the test group. We rep ort here, the existen ce o f a positive correlation between spec ific IgE and skin reaction by prick test in ato pic subjects (R=0.433). A negative correlation between specific IgE and IgG4 subclass was also found (R=-0.576). These data may be useful to und erstand the mechanism o f allergy to saffron and may help in clarifying clinical mani festation s and to prevent IgE production as well as therapeutic application,