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Synthesis and in vitro Cytotoxicity Studies of Novel Triazolo[4,3-b]pyridazinones

Rakib E.M. نويسنده , Abouricha S. نويسنده , Hannioui A. نويسنده , Benchat N. نويسنده , Zyad A. نويسنده , Ait M’barek L. نويسنده

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New triazolo[4,3-b]pyridazinones were synthesized and evaluated for their potential in vitro cytotoxic antitumor properties. The compounds were prepared by 1,3-dipolar cycloaddition of pyridazin-3-ones with N-aryl-C-ethoxycarbonylnitrile imines, generated in situ from ethylhydrazono-ل-bromoglyoxylates. The peri- and regioselectivity of the reaction were ascertained by 1H and 13C NMR spectroscopy of the cycloadducts.

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