چكيده لاتين :
Mustard gas (MG), as a chemical warfar e agent was used by the Iraqi army in Iran-Iraq
co nflic t against mil itary men in the battl efi eld in 1985.
T he se rum level s of IgG, Ig/\ and 19M o f patients exposed to MG in th e battl efield were
measured by sing le rad ial immunodi ffusion fro m da y 3 up to o ne month afte r ex posure to
MG.
The serum levels o f IgG in pati ents sh owed signdica nt decr ease o n day 3 afte r e xp osure
to MG. However, th e levels of IgG in th e se rum samples co llec ted from th e pati ents during
4-18 days after expo sure to MG were fou nd to increase. T he inc rease in serum IgG levels in
th e se ra of patients which were col lect ed d ur ing 19-31 d ays a fte r exposure to MG was found
to be highly s igni fica nt, surpass ing those from the co ntro ls, The level s of se ru m 19A in
pati ents during o ne month a fte r ex posure to lיvIG showed alte ra tio ns simila r to th o se o f
ser um IgG , howeve r the se rum a lte ratio ns o f th e patien ts Ig A, comparing to th o se o f th e
normal controls we re not signifi can t. T he ser um lev el s of IgM in pa tients did not sh ow
marked alterations d uring one month a fte r exposure to MG comparing to those of th e
no rm al controls.
The initial decr ease in se rum levels of IgG in pati ents is di scussed in term s o f a possible
leak age o f IgG in to the skin bli sters an d in to o the r severe ly a ffec ted parts o f th e body su ch
as respirat ory sys tem, wh ereas th e sub seq ue nt in cr ease in se rum IgG is interpreted as due to
(auto) antigeni c stimulatio n of th e pa tie ntsי immune sys tems.
