چكيده لاتين :
Gamma-aminobutyric acid (GABA) is an important inhibitory transmitter in
central nervous system and is involved in pathophysiology of epilepsy. Pentylenetetrazole
(PTZ), a convulsant agent, partly acts via anion channel of GABAA receptor.
Ivermectin, an antiparasitic agent and a GABAA agonist, has anticonvulsant effect
in animal seizure models. Cholestasis increases the threshold of PTZ-induced
clonic seizure in mice. The object of this study was to clarify the involvement of
GABAergic pathways in increasing PTZ-induced seizure threshold (ST) in cholestatic
mice. The result of this study showed that cholestasis increases clonic ST three days
after surgery while sham-operated control (SOC) and unoperated control (UOC)
groups did not show any alteration in clonic ST. Bicuculline, a GABAA antagonist,
reversed but ivermectin increased the clonic ST in UOC, SOC and bile duct-ligated
mice, respectively. In conclusion, our results showed that: (1) acute cholestasis is
associated with an increase in PTZ-induced clonic ST in mice and this phenomenon
may be the result of reinforcement of GABAergic system, and (2) GABA plays a
physiological role in regulation of ST.
