چكيده لاتين :
BACKGROUND: As, acid negatively affects duodenal and gastric mucosal defense, we designed this study to investigate
if fasting during Ramadan can promote peptic ulcer and its complication, acute upper gastrointestinal bleeding.
METHODS: All patients files who had admitted to hospital with acute upper gastrointestinal bleeding from 10th day of
Ramadan till one month later, in 2002 to 2004 were reviewed. Patients were divided into two groups: fasting group who
were fasting, at least 10 days before admission and non-fasting group.
RESULTS: A total of 236 patients were included in the study; fasting group involved 108 subjects and non-fasting group
128 ones. Both groups were matched regarding sex, predisposing factors and underlying diseases. Fasting group
showed more frequent duodenal ulcer (38%) compared to non-fasting group (19.5%) (P = 0.002). The frequency of esophageal
varices was significantly higher in non-fasting group. There was no correlation between fasting and other
causes of gastrointestinal bleeding. In fasting group 38%, and in non-fasting group 18.9%, had previous dyspeptic
symptoms (P = 0.001). Two groups were similar regarding prognostic factors.
CONCLUSION: It seems Ramadan fasting can increase acute upper gastrointestinal bleeding due to duodenal ulcer, but it
does not make its prognosis poorer than that in non-fasting patients. Dyspeptic symptoms could be considered as alarming
signs for patients who want to fast during Ramadan.
