19958

The role of central endogenous histamine and H1, H2 and 8 3 receptors on food intake in broiler chickens

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The role of endogenous histamine and H), H2 and H) central receptors on food intake in broiler chickens was investigated. For this purpose, a probe was used to manipulate the concentration of endogenous histamine by intracerebroventricular (ICV) injection of thioperamide, an H3 receptor antagonist, and R-amethylhistamine, an H3 receptor agonist and subsequently the effects of brain histaminergic system on food intake was assessed. Moreover, to determine the receptors involved in histamine-induced feeding behaviour changes, HI and H2 blockers were administered to thioperamide-treated chickens. Injection of thioperamide (600 and 300 nmol) decreased food intake dose-dependently (P<0.05). On the contrary, ICV injection of R-amethylhistamine (400 and 200 nmol) increased food intake (P

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