پديد آورندگان :
Reisi Nahid نويسنده , Azhir Afshin نويسنده , Hashemipour Mahin نويسنده , Raeissi Pouran نويسنده , Amini Abasgholi نويسنده , Moafi Alireza نويسنده
چكيده لاتين :
BACKGROUND: To determine the prevalence of metabolic syndrome in survivors of childhood leukemia in Isfahan, Iran.
METHODS: During a 4-year period (2003 to 2007), 55 children (33 male and 22 female) diagnosed with ALL at Unit of
Hematology/ Oncology, Department of Pediatrics, Isfahan University of Medical Science, were enrolled in this crosssectional
study. Metabolic syndrome was defined using the modified version of Adult Treatment Panel (ATP III) criteria.
Insulin resistance was defined based on the homeostasis model assessment index (HOMA-IR).
RESULTS: The mean age of participates was 10.4 years (range 6-19 years) and the mean interval since completion of
chemotherapy was 35 months. Twenty percent (11/55) of survivors (10 male, 1 female) met criteria for diagnosis of
metabolic syndrome. Obesity was observed in one forth of patients and nearly 3/4 of obese patients had metabolic syndrome.
High serum insulin levels were found in 16% of participants and in 63% of obese survivors. The mean insulin
levels in survivors with metabolic syndrome was three-times more than those without (28.3 mu/l vs. 9.57 mu/l, p =
0.004). Insulin resistance was detected in 72.7% of survivors with metabolic syndrome and it was positively correlated
with serum triglycerides (0.543, p < 0.001), systolic and diastolic BP (0.348, p = 0.01 and 0.368, p = 006 respectively),
insulin levels (0.914, p < 0.001) and blood sugar (0.398, p = 003).
CONCLUSIONS: The prevalence of metabolic syndrome in survivors of childhood leukemia in Iran is higher than developed
countries. Nearly all of the obese patients had metabolic syndrome. Weight control and regular physical exercise
are recommended to the survivors.