پديد آورندگان :
Ashrafi Mahmoud نويسنده , Jamshidi Masoud نويسنده , Fareed Mahdi نويسنده , Sanei Mohmmad Hosein نويسنده
چكيده لاتين :
When we perform surgery in utero, lungs have an appropriate time to decrease magnitude of hypoplasia,
with surgery in uterus.
METHODS: Six time-dated single-fetus ewes were selected to induce diaphragmatic hernia. Fetal lambs were divided
proportionally into 2 groups, namely group 1, diaphragmatic hernia and tracheal ligation (TL group), and group 2, diaphragmatic
hernia only (NL group). Morphologic assessments (weight, volume, bronchiolar branching) and histological
tests (lung maturation phase) were performed.
RESULTS: Lung weight in relation to lamb weight in the tracheal ligation group differed significantly from the control
group (P<0.006 in the right lung and P<0.005 in the left lung). Other parameters were markedly different between the
two groups. Lung volumes in relation to lamb weight were 29.88 ± 12.54 in the tracheal ligated group [TL] and 6.44 ±
1.84 in the non-ligated [NL] group in the right lung and 21.52 ± 7.58 in the TL group and 3.86 ± 1.90 in the NL group
in the left lung. All parameters were in favor of tracheal ligation. Lung maturation phase arrested in the canalicular
phase in the NL group and continued to the saccular phase in the TL group.
CONCLUSIONS: Tracheal ligation resulted in more mature lungs in the TL group.
