پديد آورندگان :
Vatal1ara A نويسنده , Rouholamini Najafabadi A نويسنده , Gilani K نويسنده , Asgharian R نويسنده , Darabi M نويسنده , Rafiee-Tehrani M نويسنده
چكيده لاتين :
Background: The ability of supercritical fluids (SCFs), such as carbon dioxide, to dissolve
and expand or extract organic solvents and as result lower their solvation power, makes it
possible the use of SCFs for the precipitation of solids from organic solutions. The process
could be the injection of a solution of the substrate in an organic solvent into a vessel
which is swept by a supercritical fluid. The aim of this study was to ascertain the
feasibility of supercritical processing to prepare different particulate forms of fluticasone
propionate (FP), and to evaluate the influence of different liquid solvents and precipitation
temperatures on the morphology, size and crystal habit of particles.
Method: The solution of FP in organic solvents, was precipitated by supercritical carbon
dioxide (SCC02) at two pressure and temperature levels. Effects of process parameters on
the physicochemical characteristics of harvested microparticles were evaluated.
Results: Particle formation was observed only at the lower selected pressure, whilst at the
higher pressure, no precipitation of particles was occurred due to dissolution of FP in
supercritical antisolvent. The micrographs of the produced particles showed different
morphologies for FP obtained from different conditions. The results of thermal analysis of
the resulted particles showed that changes in the processing conditions didnיt influence
thermal behavior of the precipitated particles.
Evaluation of the effect of temperature on the size distribution of particles showed that
increase in the temperature from 40°C to 50 "C, resulted in reduction of the mean particle
size from about 30 urn to about 12 ?m.
Conclusion: From the results of this study it may be concluded that, processing of FP by
supercritical anti solvent could be an approach for production of diverse forms of the drug
and drastic changes in the physical characteristics of microparticles could be achieved by
changing the type of solvent and temperature of operation
