پديد آورندگان :
Mostafavi Abdolmaleky Hamid نويسنده , Ahmadkhaniha Hamid Reza نويسنده , Nohesara Shabnam نويسنده , Smith Cassandra L نويسنده
چكيده لاتين :
The molecular mechanisms of the fact that more than 50% of the individuals with the same genetic make up
(e.g. identical twins in schizophrenia) do not show the same psychiatric phenotype remained undefined in
psychiatry. This along with the failure to find responsible genes with major effects in psychiatric disorders and
lack of consistency of genetic association studies led to the current unanimous conclusion that, in addition to the
genetic factors, environmental and epigenetic factors influence the functions of brain and the presentation of the
symptoms in mental diseases. Here we reviewed the potential epigenetic dysregulations of genes related to
dopaminergic (DAergic) system. A comprehensive genetic and epigenetic analysis of the DAergic and the
interacting pathways such as serotoninergic and glutaminergic systems could help to understand the molecular
bases of the differences in disease severity in individuals with similar or identical genetic make-up that can assist
for the identification of novel targets with therapeutic and preventive applications.
Iranian Journal of Psychiatry and Behavioral Sciences (IJPBS), Volume 2, Number 1, Spring and Summer 2008: 4-13.
