مرکز منطقه ای اطلاع رساني علوم و فناوري -

چكيده لاتين :

The aim of the present study was to determine the effect of lycopene on hypercholesterolemia in New Zealand male rabbits. Rabbits (n = 25) were divided into five groups (n = 5) and fed a nonnallaboratory diet (NC), a high cholesterol (HC) (0.5 g/100 g) diet, a high cholesterol diet with 42.6 ppm (HC-LYC1), 85.2 ppm (HC-LYC2) and 127.8 ppm (HC-LYC3) lycopene, respectively. Rabbits were fed their respective diets for 12 weeks. Serum was analyzed for lipids: total cholesterol (TC), (triacylglycerol) TG, LDL-C (low density lipoprotein-cholesterol), High density lipoprotein-Cholesterol (HDL-C) and apolipoproteins Al (Apo AI) and B (Apo B). Livers were collected for measurement of HMG-CoA reductase and ACAT activities and atherosclerotic plaque formation were assessed in aorta. Results showed that rabbits fed HC-LYC1, HC-LYC2 and HC-LYC3 had significantly (p~0.05) lower serum TC, LDL, TG, ApoB and significantly higherHDL and Apo Al levels compared to the control-HC. HDL-C (mmol L-1) in HC-LYC1, HC-LYC2 and HC-LYC3 were 2.81,2.99 and 3.71, respectively compared to 1.93 in the control-HC group. There was a highly significant (p~O.OOOl) reduction in hepatic HMG-CoA reductase levels in the groups fed the lycopene diets (HC-LYC1, HC-LYC2 and HC-LYC3) compared to the control-HC. A significant (p~0.05) reduction in ACAT activity was seen as lycopene levels increased. The percent of atherosclerotic plaque in the aorta of the rabbits fed the control-HC diets (41.5%) was reduced to 14.8 ppm when lycopene was added to the diet at 127.8 ppm. The results of this study demonstrated that lycopene might playa significant role in the prevention of cardiovascular diseases