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The Effects of Pre and Post Training Administration of MK-801 in Dorsal Hippocampus on Learning and Memory in Adult Male Rats

Moazedi A.A نويسنده , Valizadeh Z.Z نويسنده , Parham Gh.A نويسنده

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The aim of the present study was to investigate the effects intra-dorsal hippocampus (intraf.Aj) injection of NMDA receptor noncompetitive antagonists (MK-801) on memory retention using passive avoidance learning. The antagonist was administered pre and post-behavioral training. In the first experiment adult Wistar rats were given saline or MK-801 (1 ug rat-I) 10 min prior to training for 4 days, while in the second experiment saline or MK-801 (1 ug rat-I) were given immediately after training for 4 days. Post-training administration of MK-801 did not affects memory retention, in contrast to pre-training injection of MK-801 which decreased memory retention. The results suggest that pre-training injection of the non competitive antagonist NMDA receptor (MK-801) in hippocampus impaired learning and memory but post-training administration ofMK-801 did not effect on learning and memory in passive avoidance learning task.

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