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Metronidazole Resistance of Helicobacter pylori Clinical Isolates in a Hospital in Iran and Protein Pattern of Two Strains Showing Differences in Susceptibility

Nakhaei Moghaddam Mahboobeh نويسنده , Nakhaei Moghaddam Mohammad نويسنده

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Metronidazole resistant H. pyloriיs clinical isolates from biopsy specimens at a university hospital in Northeast Iran were examined. Anti-Helicobacter pylori assay was performed by the filter paper Disc Diffusion Method (DDM) on modified egg yolk emulsion agar. Twenty two (56.41 %) of39 pure isolates of H. pylori were resistant to metronidazole. Metronidazole sensitivity determination ofH pylori isolates before treating patients is essential. Protein patterns of two strains showing differences in susceptibility toward metronidazole were different which indicates variation between two strains ofH. pylori.

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