چكيده لاتين :
A simple and accurate spectrophotometric method for the determination of metronidazole in pure and pharmaceutical dosage
forms has been developed. The proposed method is based on the reduction of the nitro group to amino group of the drug. This can
be achieved by heating a mixture of an alcoholic solution of metronidazole, zinc powder and dilute hydrochloric acid in a water
bath at 90 C for 15 min. The cold and clear filtrate reacts with p-benzoquinone to develop a purple color, which absorbs
maximally at 526 nm. The calibration graph is linear over the concentration range of 15-190 ƒ g ml-1 with a molar absorptivity of
1.09 l mol-1 cm-1. The proposed method is applied to commercially available pharmaceutical dosage forms and the results
are statistically compared with those obtained by the reference method.
