پديد آورندگان :
KARIMI MEHRAN نويسنده , Panahandeh Shahraki Golam Reza نويسنده , Yavarian Majid نويسنده , Afrasiabi Abdolreza نويسنده , Dehbozorgian Javad نويسنده , Bordbar Mohammadreza نويسنده , Mannucci Pier M. نويسنده
چكيده لاتين :
Normal hemostasis requires balanced regulation of prothrombotic
and antithrombotic factors. Inherited alteration of factor V
and prothrombin gene, the G20210A mutation, increases the resistance
of factor V to degradation and booster production of
prothrombin respectively. These alterations can increase hypercoagulability
leading to thrombotic consequences. We aimed to
assess the frequencies of these mutations in a group of the population
of southern Iran. In total, 198 healthy volunteers with the
age range of 1-64 years were selected and screened for factor V
Leiden and prothrombin mutations using polymerase chain reaction
and restriction fragment length polymorphism techniques.
The carrier frequencies for factor V Leiden and prothrombin mutation
in the studied cohort were 4.1% and 3.07%, respectively.
In the studied area, the allele frequency of factor V is
higher than the prothrombin G20210A mutation (0.0204 v
0.0153). According to the data and Hardy-Weinberger equation,
the total risk of thrombosis caused by homozygosity and
heterozygosity of factor V Leiden, prothrombin G20210A mutation
and compound heterozygosity of these mutations are
about 1 in 500 individuals.
Iran J Med Sci 2009; 34(2): 137-140.
