21298

Antinociceptive Effect of Rosa damascena in Mice

Rakhshandeh Hassan نويسنده , Vahdati-Mashhadian "Nasser نويسنده , Dolati Karim نويسنده , Hosseini Mahmoud نويسنده

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In this study, analgesic effects of the aqueous, ethanolic and chlorofonnic extracts of this plant were investigated. Mice were treated with IP injection of 100, 500 and 1000 mg kg-1 aqueous, ethanolic and chlorofonnic extracts of the plant and analgesic effects were assessed using hot plate and tail flick methods. The results showed that ethanolic extract had significant analgesic effect comparable to morphine. As, pretreatment of animals with naloxone significantly reduced analgesic effect of the extract, the analgesic effect of ethanolic extract seems to be at least, in part through opioid system. No analgesic effects have been observed with aqueous or chlorofonnic extracts of the plant.

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