21715

Green Protocol for Synthesis of the 3,5-Disubstituted 1,2,4-Thiadiazoles Using N Benzyl- DABCO-Tribromide in Aqueous Media

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A novel and simple method for rapid conversion of thioamides to the corresponding 1,2,4-thiadiazole derivatives was developed. It was shown that, thioamides undergo clean and efficient oxidation and cyclization in their conversion to 1,2,4- thiadiazoles using N-benzyl-DABCO-tribromide in wet solid-solid conditions.

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