چكيده لاتين :
Regeneration of large bone defects is considered a challenging task by facio-mandibular
and orthopedic surgeons. In these circumstances, either bone grafts or metal implants are
currently being used. The inherent limitations associated with these methods have directed
the attention of investigators to new technologies such as bone tissue engineering, a multidisciplinary
field in which life science as well as engineering is involved to manufacture an
appropriate bone construct. The objectives of scientists involved in this field are to design
and manufacture scaffolds with appropriate chemical and physical features, to direct cell differentiation
within the scaffold using appropriate culture conditions and finally to render the
engineered construct applicable for clinical use. In this article, the main components involved
in the bone tissue engineering process have been reviewed. These include cells (with an
emphasis on mesenchymal stem cells), scaffolds, growth factors and bioreactors, and tissue
engineering approaches to tissue regeneration.
