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Immunogenicity of recombinant hepatitis B vaccine in health care worker of Boo-Ali hospital in Tehran, Iran, 2002-2004

Taghavi Nikdokht نويسنده , Eilami Orang نويسنده , Nabavi Mahmoud نويسنده , Azargashb Eznollah نويسنده , Yadegarynia Davod نويسنده , Alizadeh Afshin Mohammad نويسنده

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Background: Although recombinant hepatitis B vaccine is effective in a majority of population, a significant percent may do not response (up to 10%). Old age, obesity, heavy smoking and immunologic impairment have been associated with lower anti -HBs responses. In the present study, the efficacy of vaccine and effects of the abovementioned factors have been evaluated. Materials and methods: Of 111 health care workers in Boo-Ali hospital, 72 participants completed primary vaccination series and antibody tittering. They received 20Jlg of recombinant HBY vaccine (Heberbiovac, Cuba) in standard schedule. Anti-HBs was determined by ELISA test (Diakey, South Korea) one month following the third dose. Results: The lowest completion rate was reported among nursing staff and physicians (17%). Seroprotection (anti-HBs 2:10IU/L) was achieved in 86.1% of participants. Among seroprotected individuals, 52.8% were low-responders (antiHBs titer of 10-99IU/L) and 33.30/0 were good responders (anti-HBs titer of >100IU/L). The independent predictors of responsiveness were age less than 40 (OR=3.5, 950/0CI=1.8-14.6, p<0.05), non-smoking status (OR=2.9, 95%CI=1.517.2, p