پديد آورندگان :
Ramli N نويسنده , Rahmat K نويسنده , Mah E نويسنده , Tan LK نويسنده , Waran V نويسنده , Chong HT نويسنده
چكيده لاتين :
Background and Purpose: Clinical and radiological findings of intracranial abscesses may mimic the findings of
brain tumours and vice versa. However, the discrimination is of great clinical importance in planning treatment and in
following prognosis and response to therapy. This study evaluates the Computed Tomography (CT) perfusion
parameters, especially the permeability index, with the aim of evaluating the usefulness of dynamic CT perfusion
imaging as an alternative tool to differentiate necrotic brain tumours and intracerebral abscesses.
Materials and Methods: A total of 21 patients underwent perfusion CT study and were divided into 2 groups:
Group 1, patients with necrotic brain tumours (n=13); and Group 2, patients with cerebral abscesses (n=8). The mean
perfusion parameters were obtained from the enhancing part of the lesion. The relative ratios were then calculated by
using the results from mirrored regions within the contralateral hemisphere as reference.
Results: The results of this study showed that there was significant difference in the relative permeability surface
values between necrotic brain tumours and cerebral abscesses (p=0.005). By applying the ROC curve, a value of 25.1 for
rPS was found to be the best estimate to distinguish necrotic brain tumours from cerebral abscesses with a specificity of
88 % and sensitivity of 70 %.
Conclusion: CT perfusion, especially permeability surface, may allow for better differentiation of cerebral
abscesses from brain tumours, making it a strong additional imaging modality in the early diagnosis of these two entities.