التاثيرات المرضية النسجية لعقار الدوكسوروبسين على البنكرياس في ذكور الجرذان البيض

Histopathological effects of Doxorubicin on pancreas in male Albino rats I.A. Ali1, H.J. Jumaa1 and H.Kh. Ismael2 1 Department of Biology, College of Science, 2 Department of Pathology and Poultry Diseases, College of Veternary Medicine, University of Mosul, Mosul, Iraq Abstract The aim of this study was to investigate the histopathological side effects of doxorubicin on pancreas tissue in male albino rats Rattus norvegicus. This study were used 55 adult rats (2.5-3.5) month of age. The rats divided into two groups, the first group include (35) rats. The second group were (20) rats. Microscopial examination of pancreas lesion demonstrated oedema around the acini, swelling of the epithelial cells of acini, occurance of cystic fibrosis (mucoviscidosis) at the concentration of (4,5) mg/kg of body weight ,occurrence of small islets that form of few cells and exocrine-endocrine transformation. There were thickness in the walls of blood vessels, thrombus, congestion of blood vessels, we conclude, that doxorubicin had histopathological effect on pancreas in sub-acute doses more than chronic doses.