تقييم التاثير الوقائي للدايفينھايدرامين ضد التسمم الحاد بالليفاميزول في ذكور الفئران

The aim of this study was to evaluate the protective effect of different doses of diphenhydramin against acute toxicosis with Levamisole. The Mechanism of levamisole induced acute toxicity and that of protective effect of diphenhydramin against Levamisole toxicosis also examined on the level of cholinesterase (ChE) activity. Subcutanous injection of 100mg/kg levamisole in male mice with induced cholinergic over stimulation and death in 100% of animals. The Toxicosis was not related to the significantly decreased in plasma, red blood cells and brain ChE activity. Injection low dose of diphenhydramin 2.5mg/kg S.C. 15 min before levamisole produced protective effect against acute toxicity with levamisole. Significantly decreased the severity of toxicosis and increased survival rates to 100%. Diphenhydramin at low dose alone or with acute dose of levamisole did not Produced Significantly inhibition in ChE activity.The data suggested that the toxic effect of Levamisole was not related to inhibition of ChE. The low dose of diphenhydramin protected mice from Levamisole toxicity. The antidoatal effect of diphenhydramin not at the level of protection from ChE inhibition. There was no adverse interaction between two drugs.