پديد آورندگان :
Jasim, Fadhil University of Baghdad - College of Science - Department of Chemistry, Iraq , Khammas, Zuhair AA. University of Baghdad - College of Science - Department of Chemistry, Iraq , AL-Ayash, Ashraf .S. University of Baghdad - College of Science - Dept of Chemistry, Iraq
چكيده فارسي :
The drug desferrioxamine mesylate (DFOM) forms with vanadium (v) a colored chelate (λ max = 460 nm) complex at pH – range (1- 1.34 ) which is extractable with Benzyl alcohol as organic solvent . Under the appropriate experimental conditions a calibration plot was set up from which some analytical parameters were derived and deduced by regression .Standard additions procedure was also adopted .It has been estimated that the concentration of the drug DFOM to be 487.6 mg per unit and 485.1 mg per unit for both calibrations. Under optimal conditions, the developed method has LDR (2.0 – 275 μ g ml -1) DFOM, RSD % (0.3- 0.45), sandell sensitivity (0.158 μ g. cm-2), LOD (0.5 μ g ml -1), recovery %(101.466 ± 0.763), Erel %(1.466). stability constant ( 2.1x 107M -1).The mole – ratio method ( 1:1) approved that DFOM V (v) as a structure of the complex. The developed procedure has been adapted to analyze DFOM in various pharmaceuticals .
