تحضير وتشخيص عدد من معقدات السكارين والاسبرين مع بعض الفلزات ودراسة تاثيره على مصل الارانب المصابة بداء السكري

Preparation and diagnosis of a number of complexes saccharin and aspirin with some divalent metals and study its effect on the serum of infected rabbits diabetes

The first part of the research included preparation and diagnosis of a number of complexes of nickel manganese zinc and bilateral cobalt from interaction with the metal salt of saccharin with saccharin ligand which makes complexes or saccharin metal ligand. After preparation of these ligands their reactance done with aspirin as 2:1 percentage of aspirin is 2 ligand percentage is 1 by dissolving it by Ethanol evaporation done for two hours and 30 minutes then the precipitate nominated and washed and its crystallizatior returned by Ethanol and new complex of aspirin and metal saccharin been. I diagnosed prepared complex by spectral ways which included infrared spectroscopy UV spectrum molar conductivity NMR and magnetic sensitivity. Second part of this research included study of biological effectiveness of four prepared complexes at glucose and cholesterol and triple gilceridemia levels in serum by testing it on rabbits infected diabetic and non- infected rabbits the results showed that these complexes are effective Influential and led to a reduction in the level of glucose and cholesterol and triple gilceridemia levels in serum after introduction of diabetes in rabbit by hydrogen peroxide concentration 50% Rabbits were divided into three groups set control a8 rabbit: .diabetes : the number of infected rabbits infected 16 . non- infected treatment complexes : the number of rabbits 16. When we give non- infected rabbits these complexes by oral way for two weeks the study showed significant of glucose and cholesterol and gliceridemia levels . The number of infected rabbits which introduced by hydrogen peroxide concentration of 100mg/kg and concentration of 50% we specified the influential dose at 100mg/kg when gave the rabbits orally after starving them for 24 hours before taking the blood we observed during this study great effect of these complexes in reducing glucose observed significant difference between Diabetic group introduced by Hydrogen peroxide and the group treated by these prepared complexes (p 0.05) also observed significant difference in cholesterol (p 0.05) between Diabetic group and treated group which means there is significant difference of cholesterol also there is significant difference (p 0.05) in triple gilceridemia