Histological study of Bisphenol-A effect on the adrenal gland in the female rats

The present study found that the great effects of Bisphenol-A (BPS) on adrenal gland. There were two groups of pregnant gestation rats that administered bisphenol-A at dose 50mg/kg orally, one treatment group give Bisphenol- A day, days 6 of gestation to dilivery. Control group was administered with the corn oil . The administration was continuous for the rats fetuses until weaning period subsequently, the adrenal gland was taken from the sixteen puberty rats fetuses ,eight control and eight treatment with Bisphenol-A and Ex amined under light microscope . The histological results revealed that the cells of treatment adrenal gland contain less granules in cytoplasm than adrenal of group control, this study also showed that the cortex in treatment group thinner than cortex of control group in this state give indicate the treatment adrenal gland has weakness in their secretion. The medulla has numerous of follicles which contain (7-10) chromaffin cells as well as that, the treatment group thinner than control group.