Synthesis of Some New pyrazoline Compounds Derived from chalcones Compounds and Study Their biological activity

In this work, α- β- unsaturated compounds (w1-9) have been prepared from the reaction of acetophenone derivatives with appropriate aromatic aldehydes in presence of NaOH(10%),The research included synthesis of pyrazoline from the reaction of semicrbazid with chalcones yieldedscompounds(W10-18)3.3-di-p.toly-4,5dihydro-1Hpyrazole-1-Carboxamide). All thesesy ntheized compounds were characterized on the basis of their(IRand H1NMR) . The study is showed biological activity for chemical compounds, at three concentration 0.01,0.001,0.0001)mg/ml The minimum inhibitory concentration [MIC] have been determined with the reference of stander drugs the results showed that the pyrazoline derivatives are better than growth of both types of bacteria (gram- positive and garm–negative compared to drug.