SYNTHESIS AND CHARACTERIZATION OF SOME NEW MONOCYCLIC β- LACTAMS

Two compounds of 3-alkyl azetidine-2-one have been synthesized via Schiff bases in the presence of triethylamine with phosphorusoxychloride The active acid chloride react with triethylamine to generate corresponding ketene in situ which further react with Schiff’s base to furnish the corresponding 3-alkyl azetidine-2-one in moderate yields. The structures of the newly synthesized compounds were confrmed by 2D NMR(HMQC, 1H-13C,COSY1H-1H) and mass spectroscopy,which showed the proposed stereochemistry of this derivatives