Study of Serum B-HCG Positivity Regression after Hydatidiform Mole in a Sample from the Department of Obstetrics Gynecology at Damascus University Hospital

Background Objective: Gestational trophoblastic disease is a group of disorders characterized by elevated HCG, a constellation of clinical symptoms, and may be classified into benign and malignant conditions . To evaluate spontaneous regression curves of B-HCG in patients with complete mole and partial mole. Materials Methods: This prospective study conducted between the period 2007-2009 at the Obstetrics and Gynecology hospital at Damascus University. Blood samples were obtained from all patients referring or presenting to Obstetrics and Gynecology hospital at Damascus University to measure the levels of serum B-HCG by Enzyme linked Fluorescent Assay (ELFA). Results: 49 hydatidiform moles (81.7%) presented spontaneous remission of the disease. There are 11 cases of hydatidiform mole (18.3%) diagnosed as persistent trophoblastic disease based on serial levels of B-HCG. Conclusion: In this study there is no different follow up time for complete mole and partial mole, and a single undetectable HCG level post evacuation is sufficient follow up to ensure remission in patients with Hydatidiform mole.