دراسة علاجية مقارنة في فطارات الاظافر

Onychomycosis is a common fungal infection, mainly caused by dermatophytes in addition to yeasts and molds. The clinical features of Onychomycosis are abnormal color, fragility of the nail, pachyonychia, onycholysis, paronychia, and leukonychomycose. It is diagnosed by direct examination with KOH and fungal culture and rarely by biopsy. The treatment of Onychomycosis is topical and systemic antifungal agents. This research is a comparative therapeutic study of onychomycosis in 62 patients randomly divided into 3 groups: Group1: included 28 patients who received oral fluconazol 150mg, two capsules once a week. Group 2: Included 18 patients who received oral Itraconazol 100 mg, two capsules twice daily for seven days a month. Group 3: Included 16 patients who received oral terbinafine 250 mg, one tablet twice daily for seven days every month. Each drug was administered for 4 monthly pulses. As result we found that both pulse therapy of itraconazol and terbinafine were almost equal in efficacy and side effects. Both are better than pulse therapy of fluconazol in treatment of onychomycosis.