شماره ركورد
89351
عنوان مقاله
EFFICACY OF PROBIOTIC (PROTOXINE) ON MERCURY-INDUCED NEPHROTOXICITY and LIPID PEROXIDATION IN RATS
پديد آورندگان
assumaidaee, ajwad awad muhammad university of baghdad - college of pharmacy - department of clinical laboratory sciences, Iraq. , ali, nathera muhammad university of baghdad - college of pharmacy - department of clinical laboratory sciences, Iraq , akutbi, suhair hassan university of baghdad - college of pharmacy - department of clinical laboratory sciences, Iraq , fadhil, ammar amer university of baghdad - college of pharmacy - department of pharmacology and toxicology, Iraq
از صفحه
114
تا صفحه
126
تعداد صفحه
13
چكيده عربي
Mercury is the third most dangerous heavy metal and its toxicity causes serious risks to health through unfavorable pathological and biochemical effects of oxidative stress. The aim of the present study was to elucidate the possible protective role of protoxine, a probiotic, on mercuric chloride-induced oxidative stress and histopathological changes in the kidneys of the experimented rats. Adult male Wistar albino rats were daily exposed to mercuric chloride (0.25 mg kg-1) in the diet and water together for 20 days. Treatment with mercuric chloride led to oxidative stress by elevating malondialdehyde (MDA) level and also decreasing superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities. Furthermore, mercuric chloride exposure induced histopathological changes characterized by tubulonecrosis in the renal tissue of intoxicated rats. MDA level, SOD, GSH-Px activities and histopathological changes were modulated in concomitantly daily supplementation of protoxine (12 mg rat-1) to mercuric chloride-treated groups. Results from current study suggested mercuric chloride treatment resulted lipid peroxidation, alterations of enzymatic antioxidant defense system and histolopathological changes in the kidneys of male rats. The administration of protoxine proved to be beneficial in ameliorating the mercuric chloride-induced nephrotoxicity.
كليدواژه
Mercuric chloride , Oxidative stress , Nephrotoxicity , Probiotic , Histopathology.
سال انتشار
2018
عنوان نشريه
ديالي للعلوم الزراعيه
عنوان نشريه
ديالي للعلوم الزراعيه
لينک به اين مدرک