Theophylline loaded SiO2 coated iron oxide nanoparticles for targeted drug delivery

Theophylline loaded SiO2 coated iron oxide nanoparticles for targeted drug delivery

Magnetic drug targeting is a drug delivery system that can be used in Asthmatreatment. Coatedmagnetic particles, called carriers, are very useful for delivering chemotherapeutic drugs. Magnetic carrierswere synthesized by microemulsionof iron oxide followed by coating with tetraethylorthosilicate(TEOS).Characterization was carried out using X-ray diffraction, TEM, SEM, FTIR and VSM techniques. The principle of the encapsulation of iron oxide nanoparticles(Fe3O4@SiO2), with average size of 32nm. The room temperature VSMmeasurements showed that magnetic particles were superparamagnetic. the attachment of SiO2 tothe iron oxide nanoparticles was confirmed by FTIR analysis. Theophylline drug loading and releaseprofiles of SiO2 coated iron oxide nanoparticles showed that up to 70% of adsorbed drug was released in 20 h,the drug release followed the Fickian diffusion-controlled process. The binding of Theophylline to the SiO2 wasconfirmed by FTIR analysis. The present findings show that Theophylline loaded SiO2 coated iron oxide nanoparticlesare promising for magnetically targeted drug delivery.