شماره ركورد كنفرانس :
1146
عنوان مقاله :
Theophylline loaded SiO2 coated iron oxide nanoparticles for targeted drug delivery
عنوان به زبان ديگر :
Theophylline loaded SiO2 coated iron oxide nanoparticles for targeted drug delivery
پديدآورندگان :
Sharafiebgha A نويسنده
تعداد صفحه :
6
سال انتشار :
1395
عنوان كنفرانس :
دومين همايش و نمايشگاه ملي تجهيزات و مواد آزمايشگاهي صنعت نفت
زبان مدرك :
فارسی
چكيده لاتين :
Magnetic drug targeting is a drug delivery system that can be used in Asthmatreatment. Coatedmagnetic particles, called carriers, are very useful for delivering chemotherapeutic drugs. Magnetic carrierswere synthesized by microemulsionof iron oxide followed by coating with tetraethylorthosilicate(TEOS).Characterization was carried out using X-ray diffraction, TEM, SEM, FTIR and VSM techniques. The principle of the encapsulation of iron oxide nanoparticles(Fe3O4@SiO2), with average size of 32nm. The room temperature VSMmeasurements showed that magnetic particles were superparamagnetic. the attachment of SiO2 tothe iron oxide nanoparticles was confirmed by FTIR analysis. Theophylline drug loading and releaseprofiles of SiO2 coated iron oxide nanoparticles showed that up to 70% of adsorbed drug was released in 20 h,the drug release followed the Fickian diffusion-controlled process. The binding of Theophylline to the SiO2 wasconfirmed by FTIR analysis. The present findings show that Theophylline loaded SiO2 coated iron oxide nanoparticlesare promising for magnetically targeted drug delivery.
شماره مدرك كنفرانس :
4456272
سال انتشار :
1395
از صفحه :
1
تا صفحه :
6
سال انتشار :
1395
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