A Highly Efficient Nano-Fe3O4 Encapsulated-Silica Particles for the Synthesis of 2H-indazolo[2,1-b]phthalazine-trione Derivatives Under Solvent-Free Conditions

A Highly Efficient Nano-Fe3O4 Encapsulated-Silica Particles for the Synthesis of 2H-indazolo[2,1-b]phthalazine-trione Derivatives Under Solvent-Free Conditions

A novel catalytic system based on nanoparticle functionalized magnetic mesoporous silica was prepared nano-Fe3O4 encapsulated-silica particles For preparation of 2H-indazolo[2,1-b] phthalazine-trione derivatives. The procedure involves three-component condensation of aromatic aldehydes, dimedone and phthalhydrazide under solvent-free conditions. The catalyst could be easily separated from the final product using an external magnet and reused several times without consequential loss of reactivity.